TCO-PEG3-alcohol is a PEG-based linker and bioorthogonal click chemistry reagent featuring a trans-cyclooctene (TCO) group and a terminal alcohol. It undergoes rapid inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-functionalized partners, making it useful for PROTAC assembly, bioconjugation, and selective labeling in chemical biology. High purity and defined molecular weight support synthetic applications.
- Enables rapid iEDDA click reactions with tetrazines.
- Provides a PEG3 spacer for improved solubility and flexibility.
- Contains a terminal alcohol for downstream functionalization.
- High purity suitable for synthesis and conjugation workflows.
- Compatible with PROTAC synthesis and bioconjugation applications.